Spermidin and eugenol Integrator: a new Offensive against COVID-19 (SPIN OFF)

Spermidin and eugenol Integrator: a new Offensive against COVID-19 (SPIN OFF)

The main purpose of the project will be to significantly optimize the final commercial solution for the integrator, named EIT VIRAL, a nutritional supplement developed in a previous KAVA, able to decrease the ability of SARS-CoV-2 to infect host cells and replicate within them. The supplement has been formulated to be rich in the wheat germ polyamine, Spermidine, that plays a crucial role in favouring autophagy (diminished by SARS-CoV-2 infection) and a broad spectrum antiviral essential oil rich in Eugenol, which acts by decreasing viral ability to infect cells. It has been demonstrated that it possesses protective stimulatory functions against SARS-CoV-2, however it is too expensive, due to the high cost of spermidine extraction and eugenol microencapsulation. The present project aims to introduce innovations to both the product formulation and manufacture, to permit a both a successful production scale-up and cost reductions. The use of specific dietary supplements for both the prevention and treatment of SARS-CoV-2 infection has been encouraged by prominent medical entertainment personalities from the start of the current coronavirus pandemic. Considering the limited efficacy of existing supplements on the prevention of SARS-CoV-2, the added value and benefit of the EIT VIRAL supplement over existing formulations is evident. The final aim of the present KAVA is to develop a supplementary strategy for contrasting the European spread of Sars-CoV-2.